Detalhe da pesquisa
1.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A
; 121(15): e2317274121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579010
2.
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol Cell
; 70(1): 83-94.e7, 2018 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29625040
3.
In Vitro and In Vivo Characterization of NOSO-502, a Novel Inhibitor of Bacterial Translation.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987155
4.
Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.
J Antimicrob Chemother
; 73(2): 452-455, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29149329
5.
Cryptic susceptibility to penicillin/ß-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages.
Nat Commun
; 14(1): 6479, 2023 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37838722
6.
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
Clin Microbiol Infect
; 28(10): 1367-1374, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598857
7.
Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis.
Eur J Immunol
; 40(5): 1342-54, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20186878
8.
Quality and vaccine efficacy of CD4+ T cell responses directed to dominant and subdominant epitopes in ESAT-6 from Mycobacterium tuberculosis.
J Immunol
; 183(4): 2659-68, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19620314
9.
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Clin Pharmacol Ther
; 109(4): 1063-1073, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33150591
10.
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
EBioMedicine
; 73: 103652, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34740109
11.
Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice.
J Antimicrob Chemother
; 65(5): 981-5, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20233777
12.
Genomic identification of cryptic susceptibility to penicillins and ß-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.
Nat Microbiol
; 4(10): 1680-1691, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235959
13.
Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection.
Immunology
; 124(2): 175-85, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201185
14.
ENABLE: an engine for European antibacterial drug discovery and development.
Nat Rev Drug Discov
; 20(6): 407-408, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33948003
15.
Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model.
Int J Antimicrob Agents
; 42(3): 272-5, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23837927
16.
Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes.
Vaccine
; 29(37): 6283-91, 2011 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21722683
17.
Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1.
J Immunol
; 179(6): 3973-81, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17785835
18.
Genetic links between the acute-phase response and arthritis development in rats.
Arthritis Rheum
; 46(1): 259-68, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11817600